1. Katon W, Lin E, Von Korff M, Russo J, Lipscomb P, Bush T. Somatization: a spectrum of severity. Am J Psychiatry 1991;148:34–40. PMID:
1984704.
2. Rief W, Hessel A, Braehler E. Somatization symptoms and hypochondriacal features in the general population. Psychosom Med 2001;63:595–602. PMID:
11485113.
3. Lipowski ZJ. Somatization: the concept and its clinical application. Am J Psychiatry 1988;145:1358–1368. PMID:
3056044.
4. Barsky AJ, Orav EJ, Bates DW. Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity. Arch Gen Psychiatry 2005;62:903–910. PMID:
16061768.
5. Anglade P, Tsuji S, Agid Y, Hirsch EC. Neuronal plasticity and Parkinson disease. Mol Chem Neuropathol 1995;24:251–255. PMID:
7632329.
6. Thoenen H. Neurotrophins and neuronal plasticity. Science 1995;270:593–598. PMID:
7570017.
7. Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS. Neurotrophic factors: from molecule to man. Trends Neurosci 1994;17:182–190. PMID:
7520198.
8. Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289–317. PMID:
8833445.
9. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20:9104–9110. PMID:
11124987.
10. Zhivolupov SA, Samartsev IN, Marchenko AA, Puliatkina OV. [The prognostic significance of brain-derived neurotrophic factor (BDNF) for phobic anxiety disorders, vegetative and cognitive impairments during conservative treatment including adaptol of some functional and organic diseases of nervous system]. Zh Nevrol Psikhiatr Im S S Korsakova 2012;112:37–41.
11. Satomura E, Baba H, Nakano Y, Maeshima H, Suzuki T, Arai H. Correlations between brain-derived neurotrophic factor and clinical symptoms in medicated patients with major depression. J Affect Disord 2011;135:332–335. PMID:
21774990.
12. Brondino N, Lanati N, Barale F, Martinelli V, Politi P, Geroldi D, et al. Decreased NT-3 plasma levels and platelet serotonin content in patients with hypochondriasis. J Psychosom Res 2008;65:435–439. PMID:
18940373.
13. Deveci A, Aydemir O, Taskin O, Taneli F, Esen-Danaci A. Serum brain-derived neurotrophic factor levels in conversion disorder: comparative study with depression. Psychiatry Clin Neurosci 2007;61:571–573. PMID:
17875039.
14. Zhang XY, Chen DC, Tan YL, Tan SP, Wang ZR, Yang FD, et al. The interplay between BDNF and oxidative stress in chronic schizophrenia. Psychoneuroendocrinology 2015;51:201–208. PMID:
25462893.
15. Valiente-Gomez A, Amann BL, Marmol F, Oliveira C, Messeguer A, Lafuente A, et al. Comparison of serum BDNF levels in deficit and nondeficit chronic schizophrenia and healthy controls. Psychiatry Res 2014;220:197–200. PMID:
25219612.
16. Radahmadi M, Alaei H, Sharifi MR, Hosseini N. Effects of different timing of stress on corticosterone, BDNF and memory in male rats. Physiol Behav 2015;139:459–467. PMID:
25481360.
17. Niknazar S, Nahavandi A, Peyvandi AA, Peyvandi H, Akhtari AS, Karimi M. Comparison of the adulthood chronic stress effect on hippocampal BDNF signaling in male and female rats. Mol Neurobiol 2016;53:4026–4033. PMID:
26189832.
18. Tao F, Zhang F, Huang Z, Sun B, Feng X. [Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010;24:224–226. PMID:
20464992.
19. Zeilinger S, Pinto LA, Nockher WA, Depner M, Klopp N, Illig T, et al. The effect of BDNF gene variants on asthma in German children. Allergy 2009;64:1790–1794. PMID:
19895626.
20. Constandil L, Aguilera R, Goich M, Hernandez A, Alvarez P, Infante C, et al. Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats. Brain Res Bull 2011;86:454–459. PMID:
21864655.
21. Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, et al. PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci 2012;32:6351–6363. PMID:
22553040.
22. Herradon G, Ezquerra L, Nguyen T, Wang C, Siso A, Franklin B, et al. Changes in BDNF gene expression correlate with rat strain differences in neuropathic pain. Neurosci Lett 2007;420:273–276. PMID:
17556103.
23. Li CQ, Xu JM, Liu D, Zhang JY, Dai RP. Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats. Mol Pain 2008;4:27PMID:
18637202.
24. Merighi A, Salio C, Ghirri A, Lossi L, Ferrini F, Betelli C, et al. BDNF as a pain modulator. Prog Neurobiol 2008;85:297–317. PMID:
18514997.
25. Obata K, Noguchi K. BDNF in sensory neurons and chronic pain. Neurosci Res 2006;55:1–10. PMID:
16516994.
26. Stefani LC, Torres IL, de Souza IC, Rozisky JR, Fregni F, Caumo W. BDNF as an effect modifier for gender effects on pain thresholds in healthy subjects. Neurosci Lett 2012;514:62–66. PMID:
22395087.
27. Sivik T. Alexithymia and hypersensitivity to touch and palpation. Integr Physiol Behav Sci 1993;28:130–136. PMID:
8318437.
28. Wilhelmsen I. Somatization, sensitization, and functional dyspepsia. Scand J Psychol 2002;43:177–180. PMID:
12004956.
29. Fass R. Functional heartburn: what it is and how to treat it. Gastrointest Endosc Clin N Am 2009;19:23–33. vPMID:
19232278.
30. Koh KB, Choi EH, Lee YJ, Han M. Serotonin-related gene pathways associated with undifferentiated somatoform disorder. Psychiatry Res 2011;189:246–250. PMID:
21531467.
31. Han C, Pae CU, Lee BH, Ko YH, Masand PS, Patkar AA, et al. Fluoxetine versus sertraline in the treatment of patients with undifferentiated somatoform disorder: a randomized, open-label, 12-week, parallelgroup trial. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:437–444. PMID:
17950970.
32. Koh KB, Kim CH, Choi EH, Lee YJ, Seo WY. Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. J Clin Psychiatry 2012;73:e574–e579. PMID:
22697203.
33. Van Kempen GM, Zitman FG, Linssen AC, Edelbroek PM. Biochemical measures in patients with a somatoform pain disorder, before, during, and after treatment with amitriptyline with or without flupentixol. Biol Psychiatry 1992;31:670–680. PMID:
1599984.
34. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. fourth edition. Washington, DC: American Psychiatric Association; 1994.
35. Chang YH, Lee SY, Chen SL, Tzeng NS, Wang TY, Lee IH, et al. Genetic variants of the BDNF and DRD3 genes in bipolar disorder comorbid with anxiety disorder. J Affect Disord 2013;151:967–972. PMID:
24021960.
36. Park MH, Chang KD, Hallmayer J, Howe ME, Kim E, Hong SC, et al. Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder. J Psychiatr Res 2014;61:81–88. PMID:
25498133.
37. Brunoni AR, Baeken C, Machado-Vieira R, Gattaz WF, Vanderhasselt MA. BDNF blood levels after non-invasive brain stimulation interventions in major depressive disorder: a systematic review and meta-analysis. World J Biol Psychiatry 2014;16:114–122. PMID:
25264290.
38. Yoshimura R, Ikenouchi-Sugita A, Hori H, Umene-Nakano W, Hayashi K, Katsuki A, et al. [Blood levels of brain-derived neurotrophic factor (BDNF) in major depressive disorder]. Seishin Shinkeigaku Zasshi 2010;112:982–985. PMID:
21179660.
39. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005;26:115–123. PMID:
15585351.
40. Gervasoni N, Aubry JM, Bondolfi G, Osiek C, Schwald M, Bertschy G, et al. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiology 2005;51:234–238. PMID:
15897674.
41. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70–75. PMID:
12842310.
42. Lin CF, Juang YY, Wen JK, Liu CY, Hung CI. Correlations between sexual dysfunction, depression, anxiety, and somatic symptoms among patients with major depressive disorder. Chang Gung Med J 2012;35:323–331. PMID:
22913859.
43. Woo JM, Jeon H, Noh E, Kim HJ, Lee S, Lee K, et al. Importance of remission and residual somatic symptoms in health-related quality of life among outpatients with major depressive disorder: a cross-sectional study. Health Qual Life Outcomes 2014;12:188PMID:
25519704.
44. Garcia-Campayo J, Ayuso-Mateos JL, Caballero L, Romera I, Aragones E, Rodriguez-Artalejo F, et al. Relationship of somatic symptoms with depression severity, quality of life, and health resources utilization in patients with major depressive disorder seeking primary health care in Spain. Prim Care Companion J Clin Psychiatry 2008;10:355–362. PMID:
19158973.
45. Romera I, Fernandez-Perez S, Montejo AL, Caballero F, Caballero L, Arbesu JA, et al. Generalized anxiety disorder, with or without comorbid major depressive disorder, in primary care: prevalence of painful somatic symptoms, functioning and health status. J Affect Disord 2010;127:160–168. PMID:
20541811.
46. Stahl SM, Ahmed S, Haudiquet V. Analysis of the rate of improvement of specific psychic and somatic symptoms of general anxiety disorder during long-term treatment with venlafaxine ER. CNS Spectr 2007;12:703–711. PMID:
17805217.
47. Deschenes SS, Burns RJ, Schmitz N. Associations between diabetes, major depressive disorder and generalized anxiety disorder comorbidity, and disability: findings from the 2012 Canadian Community Health Survey - Mental Health (CCHS-MH). J Psychosom Res 2015;78:137–142. PMID:
25510185.
48. Hunt C, Slade T, Andrews G. Generalized anxiety disorder and major depressive disorder comorbidity in the National Survey of Mental Health and Well-Being. Depress Anxiety 2004;20:23–31. PMID:
15368593.
49. Phillips AC, Batty GD, Gale CR, Lord JM, Arlt W, Carroll D. Major depressive disorder, generalised anxiety disorder, and their comorbidity: associations with cortisol in the Vietnam Experience Study. Psychoneuroendocrinology 2011;36:682–690. PMID:
20952132.
50. Cubeddu A, Bucci F, Giannini A, Russo M, Daino D, Russo N, et al. Brain-derived neurotrophic factor plasma variation during the different phases of the menstrual cycle in women with premenstrual syndrome. Psychoneuroendocrinology 2011;36:523–530. PMID:
20933336.
51. Katerberg H, Lochner C, Cath DC, de Jonge P, Bochdanovits Z, Moolman-Smook JC, et al. The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessivecompulsive disorder (OCD). Am J Med Genet B Neuropsychiatr Genet 2009;150B:1050–1062. PMID:
19219856.
52. Simsek S, Uysal C, Kaplan I, Yuksel T, Aktas H. BDNF and cortisol levels in children with or without post-traumatic stress disorder after sustaining sexual abuse. Psychoneuroendocrinology 2015;56:45–51. PMID:
25800148.
53. Shi SS, Shao SH, Yuan BP, Pan F, Li ZL. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinasecoupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J 2010;51:661–671. PMID:
20635439.
54. Tognoli C, Rossi F, Di Cola F, Baj G, Tongiorgi E, Terova G, et al. Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax. BMC Neurosci 2010;11:4PMID:
20074340.
55. van Winkel M, Peeters F, van Winkel R, Kenis G, Collip D, Geschwind N, et al. Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction. Eur Neuropsychopharmacol 2014;24:930–938. PMID:
24613654.
56. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002;109:143–148. PMID:
11927139.
57. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998;37:1553–1561. PMID:
9886678.
58. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 2002;328:261–264. PMID:
12147321.