1. Morgan C, Hutchinson G. In: Morgan C, Bhugra DThe Sociodevelopmental Origins of Psychosis. , editor. Principles of Social Psychiatry. 2010,Second Edition. Chichester, UK: JohnWiley & Sons Ltd, p. 193–213.
2. Bebbington PE, Bhugra D, Brugha T, Singleton N, Farrell M, Jenkins R, et al. Psychosis, victimisation and childhood disadvantage: evidence from the second British National Survey of Psychiatric Morbidity. Br J Psychiatry 2004;185:220–226. PMID:
15339826.
3. Rutter M, Sroufe LA. Developmental psychopathology: concepts and challenges. Dev Psychopathol 2000;12:265–296. PMID:
11014739.
4. van Os J, Kenis G, Rutten BP. The environment and schizophrenia. Nature 2010;468:203–212. PMID:
21068828.
5. Chen LP, Murad MH, Paras ML, Colbenson KM, Sattler AL, Goranson EN, et al. Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clin Proc 2010;85:618–629. PMID:
20458101.
6. Leeb R, Paulozzi L, Melanson C, Simon T, Arias I. Child Maltreatment Surveillance: Uniform Definitions for Public Health and Recommended Data Elements, Version 1.0. 2008,Atlanta, GA: US Department of Health and Human Services, CDC.
7. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet 2009;373:68–81. PMID:
19056114.
8. Weich S, Patterson J, Shaw R, Stewart-Brown S. Family relationships in childhood and common psychiatric disorders in later life: systematic review of prospective studies. Br J Psychiatry 2009;194:392–398. PMID:
19407266.
9. Jonas S, Bebbington P, McManus S, Meltzer H, Jenkins R, Kuipers E, et al. Sexual abuse and psychiatric disorder in England: results from the 2007 Adult Psychiatric Morbidity Survey. Psychol Med 2011;41:709–719. PMID:
20534178.
10. Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 2010;67:113–123. PMID:
20124111.
11. Alloy LB, Abramson LY, Smith JM, Gibb BE, Neeren AM. Role of parenting and maltreatment histories in unipolar and bipolar mood disorders: mediation by cognitive vulnerability to depression. Clin Child Fam Psychol Rev 2006;9:23–64. PMID:
16718583.
12. Paolucci EO, Genuis ML, Violato C. A meta-analysis of the published research on the effects of child sexual abuse. J Psychol 2001;135:17–36. PMID:
11235837.
13. Al-Modallal H, Peden A, Anderson D. Impact of physical abuse on adulthood depressive symptoms among women. Issues Ment Health Nurs 2008;29:299–314. PMID:
18340614.
14. Rind B, Tromovitch P, Bauserman R. A meta-analytic examination of assumed properties of child sexual abuse using college samples. Psychol Bull 1998;124:22–53. PMID:
9670820.
15. Kearney CA, Wechsler A, Kaur H, Lemos-Miller A. Posttraumatic stress disorder in maltreated youth: a review of contemporary research and thought. Clin Child Fam Psychol Rev 2010;13:46–76. PMID:
20012361.
16. Ozer EJ, Best SR, Lipsey TL, Weiss DS. Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull 2003;129:52–73. PMID:
12555794.
17. Cash SJ, Bridge JA. Epidemiology of youth suicide and suicidal behavior. Curr Opin Pediatr 2009;21:613–619. PMID:
19644372.
18. Evans E, Hawton K, Rodham K. Factors associated with suicidal phenomena in adolescents: a systematic review of population-based studies. Clin Psychol Rev 2004;24:957–979. PMID:
15533280.
19. Brodsky BS, Stanley B. Developmental effects on suicidal behavior: the role of abuse in childhood. Clin Neurosci Res 2001;1:331–336.
20. Afifi TO, Enns MW, Cox BJ, Asmundson GJ, Stein MB, Sareen J. Population attributable fractions of psychiatric disorders and suicide ideation and attempts associated with adverse childhood experiences. Am J Public Health 2008;98:946–952. PMID:
18381992.
21. Afifi TO, Boman J, Fleisher W, Sareen J. The relationship between child abuse, parental divorce, and lifetime mental disorders and suicidality in a nationally representative adult sample. Child Abuse Negl 2009;33:139–147. PMID:
19327835.
22. Brezo J, Paris J, Vitaro F, Hébert M, Tremblay RE, Turecki G. Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry 2008;193:134–139. PMID:
18669998.
23. Fergusson DM, Boden JM, Horwood LJ. Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Abuse Negl 2008;32:607–619. PMID:
18565580.
24. Simpson TL, Miller WR. Concomitance between childhood sexual and physical abuse and substance use problems: A review. Clin Psychol Rev 2002;22:27–77. PMID:
11793578.
25. Enoch MA. The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology (Berl) 2011;214:17–31. PMID:
20596857.
26. Widom CS, Marmorstein NR, White HR. Childhood victimization and illicit drug use in middle adulthood? Psychol Addict Behav 2006;20:394–403. PMID:
17176174.
27. Lansford JE, Dodge KA, Pettit GS, Bates JE. Does physical abuse in early childhood predict substance use in adolescence and early adulthood. Child Maltreat 2010;15:190–194. PMID:
20019026.
28. MacMillan HL, Fleming JE, Trocmé N, Boyle MH, Wong M, Racine YA, et al. Prevalence of child physical and sexual abuse in the community. Results from the Ontario Health Supplement. JAMA 1997;278:131–135. PMID:
9214528.
29. Widom CS, White HR, Czaja SJ, Marmorstein NR. Long-term effects of child abuse and neglect on alcohol use and excessive drinking in middle adulthood. J Stud Alcohol Drugs 2007;68:317–326. PMID:
17446970.
30. Dube SR, Miller JW, Brown DW, Giles WH, Felitti VJ, Dong M, et al. Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. J Adolesc Health 2006;38:444PMID:
16549308.
31. Read J, van Os J, Morrison AP, Ross CA. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 2005;112:330–350. PMID:
16223421.
32. Morgan C, Fisher H. Environment and schizophrenia: environmental factors in schizophrenia: childhood trauma--a critical review. Schizophr Bull 2007;33:3–10. PMID:
17105965.
33. Bendall S, Jackson HJ, Hulbert CA, McGorry PD. Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull 2008;34:568–579. PMID:
18003630.
34. Murray RM, Sham P, Van Os J, Zanelli J, Cannon M, McDonald C. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr Res 2004;71:405–416. PMID:
15474912.
35. Goodman LA, Thompson KM, Weinfurt K, Corl S, Acker P, Mueser KT, et al. Reliability of reports of violent victimization and posttraumatic stress disorder among men and women with serious mental illness. J Trauma Stress 1999;12:587–599. PMID:
10646178.
36. Fisher HL, Craig TK, Fearon P, Morgan K, Dazzan P, Lappin J, et al. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull 2011;37:546–553. PMID:
19776204.
37. Shevlin M, Dorahy MJ, Adamson G. Trauma and psychosis: an analysis of the National Comorbidity Survey. Am J Psychiatry 2007;164:166–169. PMID:
17202562.
38. Shevlin M, Houston JE, Dorahy MJ, Adamson G. Cumulative traumas and psychosis: an analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey. Schizophr Bull 2008;34:193–199. PMID:
17586579.
39. Janssen I, Krabbendam L, Bak M, Hanssen M, Vollebergh W, de Graaf R, et al. Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 2004;109:38–45. PMID:
14674957.
40. Spauwen J, Krabbendam L, Lieb R, Wittchen HU, van Os J. Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. Br J Psychiatry 2006;188:527–533. PMID:
16738342.
41. Whitfield CL, Dube SR, Felitti VJ, Anda RF. Adverse childhood experiences and hallucinations. Child Abuse Negl 2005;29:797–810. PMID:
16051353.
42. Bebbington P, Jonas S, Kuipers E, King M, Cooper C, Brugha T, et al. Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey in England. Br J Psychiatry 2011;199:29–37. PMID:
21508437.
43. Galletly C, Van Hooff M, McFarlane A. Psychotic symptoms in young adults exposed to childhood trauma--a 20 year follow-up study. Schizophr Res 2011;127:76–82. PMID:
21256719.
44. Spataro J, Mullen PE, Burgess PM, Wells DL, Moss SA. Impact of child sexual abuse on mental health: prospective study in males and females. Br J Psychiatry 2004;184:416–421. PMID:
15123505.
45. Cutajar MC, Mullen PE, Ogloff JR, Thomas SD, Wells DL, Spataro J. Psychopathology in a large cohort of sexually abused children followed up to 43 years. Child Abuse Negl 2010;34:813–822. PMID:
20888636.
46. Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A. Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. Am J Psychiatry 2011;168:65–72. PMID:
20952460.
47. Schürhoff F, Laguerre A, Fisher H, Etain B, Méary A, Soussy C, et al. Self-reported childhood trauma correlates with schizotypal measures in schi-zophrenia but not bipolar pedigrees. Psychol Med 2009;39:365–370. PMID:
18588743.
48. Thompson JL, Kelly M, Kimhy D, Harkavy-Friedman JM, Khan S, Messinger JW, et al. Childhood trauma and prodromal symptoms among individuals at clinical high risk for psychosis. Schizophr Res 2009;108:176–181. PMID:
19174322.
49. Lataster T, van Os J, Drukker M, Henquet C, Feron F, Gunther N, et al. Childhood victimisation and developmental expression of non-clinical delusional ideation and hallucinatory experiences: victimisation and non-clinical psychotic experiences. Soc Psychiatry Psychiatr Epidemiol 2006;41:423–428. PMID:
16572272.
50. Kelleher I, Harley M, Lynch F, Arseneault L, Fitzpatrick C, Cannon M. Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. Br J Psychiatry 2008;193:378–382. PMID:
18978317.
51. Bechdolf A, Thompson A, Nelson B, Cotton S, Simmons MB, Amminger GP, et al. Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group. Acta Psychiatr Scand 2010;121:377–384. PMID:
20199494.
52. Rubino IA, Nanni RC, Pozzi DM, Siracusano A. Early adverse experiences in schizophrenia and unipolar depression. J Nerv Ment Dis 2009;197:65–68. PMID:
19155813.
53. Aas M, Dazzan P, Fisher HL, Morgan C, Morgan K, Reichenberg A, et al. Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophr Res 2011;129:12–19. PMID:
21601792.
54. Darves-Bornoz J, Lemperiere T, Degiovanni A, Gaillard P. Sexual victimization in women with schizophrenia and bipolar disorder. Soc Psychiatry Psychiatr Epidemiol 1995;30:78–84. PMID:
7754420.
55. Alvarez MJ, Roura P, Osés A, Foguet Q, Solà J, Arrufat FX. Prevalence and clinical impact of childhood trauma in patients with severe mental disorders. J Nerv Ment Dis 2011;199:156–161. PMID:
21346485.
56. Wexler BE, Lyons L, Lyons H, Mazure CM. Physical and sexual abuse during childhood and development of psychiatric illnesses during adulthood. J Nerv Ment Dis 1997;185:522–524. PMID:
9284868.
57. Spence W, Mulholland C, Lynch G, McHugh S, Dempster M, Shannon C. Rates of childhood trauma in a sample of patients with schizophrenia as compared with a sample of patients with non-psychotic psychiatric diagnoses. J Trauma Dissociation 2006;7:7–22. PMID:
16873227.
58. Friedman S, Smith L, Fogel D, Paradis C, Viswanathan R, Ackerman R, et al. The incidence and influence of early traumatic life events in patients with panic disorder: a comparison with other psychiatric outpatients. J Anxiety Disord 2002;16:259–272. PMID:
12214812.
59. Drake B, Pandey S. Understanding the relationship between neighborhood poverty and specific types of child maltreatment. Child Abuse Negl 1996;20:1003–1018. PMID:
8958452.
60. Coulton CJ, Crampton DS, Irwin M, Spilsbury JC, Korbin JE. How neighborhoods influence child maltreatment: a review of the literature and alternative pathways. Child Abuse Negl 2007;31:1117–1142. PMID:
18023868.
61. Fisher H, Morgan C, Dazzan P, Craig TK, Morgan K, Hutchinson G, et al. Gender differences in the association between childhood abuse and psychosis. Br J Psychiatry 2009;194:319–325. PMID:
19336782.
62. Fisher HL, Jones PB, Fearon P, Craig TK, Dazzan P, Morgan K, et al. The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychol Med 2010;40:1967–1978. PMID:
20178679.
63. Grubaugh A, Zinzow H, Paul L, Egede LE, Frueh BC. Trauma exposure and posttraumatic stress disorder in adults with severe mental illness: a critical review. Clin Psychol Rev 2011;31:883–899. PMID:
21596012.
64. Neria Y, Bromet EJ, Sievers S, Lavelle J, Fochtmann LJ. Trauma exposure and posttraumatic stress disorder in psychosis: findings from a first-admission cohort. J Consult Clin Psychol 2002;70:246–251. PMID:
11860051.
65. Resnick SG, Bond GR, Mueser KT. Trauma and posttraumatic stress disorder in people with schizophrenia. J Abnorm Psychol 2003;112:415–423. PMID:
12943020.
66. Kilcommons AM, Morrison A. Relationships between trauma and psychosis: an exploration of cognitive and dissociative factors. Acta Psychiatr Scand 2005;112:351–359. PMID:
16223422.
67. Weber K, Rockstroh B, Borgelt J, Awiszus B, Popov T, Hoffmann K, et al. Stress load during childhood affects psychopathology in psychiatric patients. BMC Psychiatry 2008;8:63PMID:
18651952.
68. Rosenberg SD, Lu W, Mueser KT, Jankowski MK, Cournos F. Correlates of adverse childhood events among adults with schizophrenia spectrum disorders. Psychiatr Serv 2007;58:245–253. PMID:
17287383.
69. Mueser KT, Salyers MP, Rosenberg SD, Goodman LA, Essock SM, Osher FC, et al. Interpersonal trauma and posttraumatic stress disorder in patients with severe mental illness: demographic, clinical, and health correlates. Schizophr Bull 2004;30:45–57. PMID:
15176761.
70. Mueser KT, Rosenberg SD, Goodman LA, Trumbetta SL. Trauma, PTSD, and the course of severe mental illness: an interactive model. Schizophr Res 2002;53:123–143. PMID:
11728845.
71. Offen L, Waller G, Thomas G. Is reported childhood sexual abuse associated with the psychopathological characteristics of patients who experience auditory hallucinations. Child Abuse Negl 2003;27:919–927. PMID:
12951140.
72. Ross CA, Keyes B. Dissociation and schizophrenia. J Trauma Dissociation 2004;5:69–83.
73. Holowka DW, King S, Saheb D, Pukall M, Brunet A. Childhood abuse and dissociative symptoms in adult schizophrenia. Schizophr Res 2003;60:87–90. PMID:
12505142.
74. Hardy A, Fowler D, Freeman D, Smith B, Steel C, Evans J, et al. Trauma and hallucinatory experience in psychosis. J Nerv Ment Dis 2005;193:501–507. PMID:
16082293.
75. Read J, Argyle N. Hallucinations, delusions, and thought disorder among adult psychiatric inpatients with a history of child abuse. Psychiatr Serv 1999;50:1467–1472. PMID:
10543857.
76. Gearon JS, Kaltman SI, Brown C, Bellack AS. Traumatic life events and PTSD among women with substance use disorders and schizophrenia. Psychiatr Serv 2003;54:523–528. PMID:
12663840.
77. Compton MT, Furman AC, Kaslow NJ. Preliminary evidence of an association between childhood abuse and cannabis dependence among African American first-episode schizophrenia-spectrum disorder patients. Drug Alcohol Depend 2004;76:311–316. PMID:
15561482.
78. Harley M, Kelleher I, Clarke M, Lynch F, Arseneault L, Connor D, et al. Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychol Med 2010;40:1627–1634. PMID:
19995476.
79. Konings M, Stefanis N, Kuepper R, de Graaf R, ten Have M, van Os J, et al. Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychol Med 2012;42:149–159. PMID:
21676285.
80. Houston JE, Murphy J, Shevlin M, Adamson G. Cannabis use and psychosis: re-visiting the role of childhood trauma. Psychol Med 2011;41:2339–2348. PMID:
21557896.
81. Houston JE, Murphy J, Adamson G, Stringer M, Shevlin M. Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophr Bull 2008;34:580–585. PMID:
18024467.
82. Kuepper R, Henquet C, Lieb R, Wittchen HU, van Os J. Non-replication of interaction between cannabis use and trauma in predicting psy chosis. Schizophr Res 2011;131:262–263. PMID:
21745727.
83. Cougnard A, Marcelis M, Myin-Germeys I, De Graaf R, Vollebergh W, Krabbendam L, et al. Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model. Psychol Med 2007;37:513–527. PMID:
17288646.
84. Howes OD, McDonald C, Cannon M, Arseneault L, Boydell J, Murray RM. Pathways to schizophrenia: the impact of environmental factors. Int J Neuropsychopharmacol 2004;7(Suppl 1):S7–S13. PMID:
14972079.
85. van Winkel R, Stefanis NC, Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull 2008;34:1095–1105. PMID:
18718885.
86. Lieberman JA, Kinon BJ, Loebel AD. Dopaminergic mechanisms in idiopathic and drug-induced psychoses. Schizophr Bull 1990;16:97–110. PMID:
2185538.
87. Read J, Perry BD, Moskowitz A, Connolly J. The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model. Psychiatry 2001;64:319–345. PMID:
11822210.
88. Collip D, Myin-Germeys I, Van Os J. Does the concept of "sensitization" provide a plausible mechanism for the putative link between the environment and schizophrenia? Schizophr Bull 2008;34:220–225. PMID:
18203757.
89. Garety PA, Kuipers E, Fowler D, Freeman D, Bebbington PE. A cognitive model of the positive symptoms of psychosis. Psychol Med 2001;31:189–195. PMID:
11232907.
90. Glaser JP, van Os J, Portegijs PJ, Myin-Germeys I. Childhood trauma and emotional reactivity to daily life stress in adult frequent attenders of general practitioners. J Psychosom Res 2006;61:229–236. PMID:
16880026.
91. Myin-Germeys I, van Os J. Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clin Psychol Rev 2007;27:409–424. PMID:
17222489.
92. Oorschot M, Kwapil T, Delespaul P, Myin-Germeys I. Momentary assessment research in psychosis. Psychol Assess 2009;21:498–505. PMID:
19947784.
93. Egerton A, Mehta MA, Montgomery AJ, Lappin JM, Howes OD, Reeves SJ, et al. The dopaminergic basis of human behaviors: a review of molecular imaging studies. Neurosci Biobehav Rev 2009;33:1109–1132. PMID:
19481108.
94. Pruessner JC, Champagne F, Meaney MJ, Dagher A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C] raclopride. J Neurosci 2004;24:2825–2831. PMID:
15028776.
95. Soliman A, O'Driscoll GA, Pruessner J, Holahan ALV, Boileau I, Gagnon D, et al. Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET Study. Neuropsychopharmacology 2007;33:2033–2041. PMID:
17957215.
96. Tarullo AR, Gunnar MR. Child maltreatment and the developing HPA axis. Horm Behav 2006;50:632–639. PMID:
16876168.
97. McCrory E, De Brito SA, Viding E. Research Review: the neurobiology and genetics of maltreatment and adversity. J Child Psychol Psychiatry 2010;51:1079–1095. PMID:
20546078.
98. Aas M, Dazzan P, Mondelli V, Toulopoulou T, Reichenberg A, Di Forti M, et al. Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychol Med 2011;41:463–476. PMID:
20529412.
99. Mondelli V, Dazzan P, Hepgul N, Di Forti M, Aas M, D'Albenzio A, et al. Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment. Schizophr Res 2010;116:234–242. PMID:
19751968.
100. Bradley AJ, Dinan TG. A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality. J Psychopharmacol 2010;24:91–118. PMID:
20923924.
101. Walker E, Mittal V, Tessner K. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol 2008;4:189–216. PMID:
18370616.
102. Pariante CM. Pituitary volume in psychosis: the first review of the evidence. J Psychopharmacol 2008;22:76–81. PMID:
18709702.
103. Alemany S, Arias B, Aguilera M, Villa H, Moya J, Ibáñez MI, et al. Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences. Br J Psychiatry 2011;199:38–42. PMID:
21719879.
104. Mondelli V, Cattaneo A, Belvederi Murri M, Di Forti M, Handley R, Hepgul N, et al. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry 2011;72:1677–1684. PMID:
21672499.