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Psychiatry Investig > Epub ahead of print
[Epub ahead of print]
DOI: https://doi.org/10.30773/pi.2018.11.18    Published online March 7, 2019.
Effect of tDCS on Aberrant Functional Network Connectivity in Refractory Hallucinatory Schizophrenia: A Pilot Study
Youngwoo Bryan Yoon1,2,3, Minah Kim4, Junhee Lee4, Kang Ik K. Cho1,2, Seoyeon Kwak1, Tae Young Lee4, Jun Soo Kwon1,2,4
1Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea
2Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea
3Department of Psychiatry, Washington University in St. Louis, MO, USA
4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
Correspondence: Tae Young Lee ,Tel: +82-2-2072-2972, Fax: +82-2-747-9063, Email: leetaey@gmail.com
Received: January 26, 2018   Revised: May 16, 2018   Accepted: November 18, 2018   Published online: March 7, 2019
Abstract
We aim to investigate the effect of fronto-temporal transcranial direct current stimulation (tDCS) on the interactions among functional networks and its association with psychotic symptoms. In this pilot study, we will determine possible candidate functional networks and an adequate sample size for future research. Seven schizophrenia patients with treatment-refractory auditory hallucinations underwent tDCS twice daily for 5 days. Resting-state fMRI data and measures of the severity of psychotic symptoms were acquired at baseline and after completion of the tDCS sessions. At baseline, decreased functional network interaction was negatively correlated with increased hallucinatory behavior. After tDCS, the previously reduced functional network connectivity significantly increased. Our results showed that fronto-temporal tDCS could possibly remediate aberrant hallucination-related functional network interactions in patients with schizophrenia.
Key words   Neuroimaging, Schizophrenia and psychotic disorder, Transcranial direct current stimulation, Auditory hallucinations, Resting-state fMRI
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